10 Best Ergonomic Mouse for Large Hands

There are many ergonomic mouse available for large hands.

They come in various shapes and sizes and have varied functionalities. If you have large hands, then you need to invest in an ergonomic mouse that is suitable for your hand size.

This is because, without proper mouse support, the constant clicking can result in a lot of discomfort and pain.

So, if you’re looking for the best ergonomic mouse for large hands, here are 10 mouse that you can choose from:

Our Pick – Top 3 Ergonomic Mouse for Large Hands

In case you’re in a hurry, here are my top three recommendations for the best ergonomic mouse for large hands.

#1	#2	#3
Logitech M570 Wireless Trackball Mouse – Ergonomic Design with...	Evoluent VM4R VerticalMouse 4 Right Hand Ergonomic Mouse with...	Microsoft Pro Intellimouse – Dark Shadow. Comfortable Ergonomic...
$	$$$	$
Check on Amazon	Check on Amazon	Check on Amazon

Still confused about which ergonomic mouse for large hands is best for you?

Let me help by providing detailed reviews on the best ergonomic mouse for large hands that I found in the market (and the ones you can buy online).

These reviews will definitely help you gain awareness and understanding of the best features, pros, and cons of each ergonomic mouse for a large hand.

Let’s get started!

Best Ergonomic Mouse For Large Hands Reviewed

Below is the table that shows all the ergonomic mouse for large hands covered in this review.

NAME	IMAGE	OUR RATING	PRICE
Logitech M570 Wireless Trackball Mouse – Ergonomic Design with...		9.5 / 10	$	Check Best Price
Evoluent VM4R VerticalMouse 4 Right Hand Ergonomic Mouse with...		9.5 / 10	$$$	Check Best Price
Microsoft Pro Intellimouse – Dark Shadow. Comfortable Ergonomic...		9.0 / 10	$	Check Best Price
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse, 800 / 1200...		9.0 / 10	$	Check Best Price
No products found.	No products found.	8.5 / 10	$$	No products found.
Logitech MX Master 2S Wireless Mouse – Use on Any Surface,...		8.5 / 10	$$$	Check Best Price
No products found.	No products found.	8.0 / 10	$$	No products found.
SteelSeries Rival 310 Gaming Mouse - 12,000 CPI TrueMove3 Optical...		8.0 / 10	$$	Check Best Price
Logitech G602 Lag-Free Wireless Gaming Mouse – 11 Programmable...		7.5 / 10	$	Check Best Price
Corsair Dark Core - RGB Wireless Gaming Mouse - 16,000 DPI...		7.5 / 10	$$	Check Best Price

Now let’s have a look at the detailed reviews of each of the ergonomic mouse for large hand covered in this article.

Logitech M570 Wireless Trackball Mouse (Best Overall Mouse For Large Hands)

Logitech M570 mouse is large in size and has a perfect grip-angle, both of which make it an ideal fit for people with large hands. This wireless mouse comes with a proficient and compact USB receiver that you can plug into the PC.

If you’re looking for an ergonomic mouse for large hands, this is out top pick.

This is the mouse that I am using currently and I love that it doesn’t need me to move my hand. Instead, I can control the trackball using the thumb. I find it extremely comfortable and easy to use. In case you’re interested, I have this full review of the Logitech M570 mouse.

The trackball has a particularly unique sculpted design and is pretty large. It’s also pretty easy to remove and clean. It is perfectly smooth to use and has good control and movement.

This mouse comes with a replaceable battery with a long battery timing of around 18 months. What’s more, is that the mouse has an automatic alert system that allows it to alert the user when the battery is dangerously low.

Additionally, the Logitech M570 mouse presents you with a large variety of modifiable options, which allow you to customize the trackball mouse to fit your needs. You simply have to install the Logitech software on the host device to manually alter the set specifications.

The software and effective receiver allow the user to have an accurate and rapid output. The fast data signal rate of the Logitech M570 also adds to its rapid response rate.

Moreover, if you want precise cursor movement, then this mouse is the ideal fit for you. The mouse also has two controls for web surfing, which allow the user to conveniently switch between webpages.

PROs	CONs
Perfect mouse for large hands Good trackball design and functionality Enduring battery life Efficient receiver	For right-handed individuals only Need cleaning after every few months

Evoluent VM4R VerticalMouse 4 Right Hand Ergonomic Mouse with Wired USB Connection (Best Wired Mouse for Large Hands)

Evoluent VM4R Mouse has a fascinating vertical design that requires a little getting used to. However, the ergonomic design allows the user to put minimal to no stress on their wrist, which significantly reduces hand and wrist pain. It also has an excellent build quality to boot.

Additionally, the Evoluent software, known as the Evoluent Mouse Manager, is a helpful tool that allows you to customize and configure the mouse buttons to meet your specific requirements.

You can even assign the copy and paste functions to your mouse buttons and so many more functions! This feature is quite helpful for people with technical jobs who need to avail of the different features of this mouse as well as gamers.

The natural handshake position of this Evoluent USB mouse is what allows the user to have a convenient browsing experience for hours on end. It also has a convenient and large thumb rest on its left-hand side, which will help you relax your hands mid-browsing.

You can also adjust the pointer speed of this mouse form low to high with the help of the optical sensor controls given on the side of the mouse.

Thanks to this convenient placement, you don’t even need to release your grip on the mouse to adjust the speed.

PROs	CONs
Hyper scrolling Helpful software Large contoured thumb rest Conveniently placed buttons	For right-handers only Design requires a little getting used to

Microsoft Pro Intellimouse – Dark Shadow

The Microsoft Pro Intellimouse ergonomic mouse comes with an up to date PixArt tracking sensor. This mouse comes with two responsive, customizable buttons, a middle click, and a firm scroll wheel. It has a traditional model design for a mouse; however, that does not affect its functionality. The mouse is quick and has a responsive pointer.

Moreover, it is highly durable due to the enhanced top key actuation lifecycle, which is designed for continual usage. It also offers enhanced skirt abrasion performance, which makes using it quite easy. It translates into an ultra-smooth response and convenient user experience.

The ergonomic, curved design of this mouse allows the user to use it for hours on end, without much stress on their hand and arms. Plus, the new and improved braided cable of the mouse offers its users a tangle-free movement. The side key texture also greatly enhances the touch perception of the user.

What’s more, is that this mouse does not lag. You simply have to plug in the wired USB connector. The wire omits the need for Bluetooth connectivity. It is also quite precise and responsive to use. Also, the durability of this mouse is quite impressive.

PROs	CONs
Firm scroll wheel Fast connectivity Ultra-durable	Stiff and noisy buttons Not wireless

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse

Anker 2.4 wireless mouse has a truly distinctive large shape; it has a height of 3.15 inches. When you use this mouse, your hand will rest in a natural handshake position, with the lower-left side facing your desk. This allows unnecessary strain on your hand and arm.

Additionally, this mouse comes with replaceable batteries with a battery timing of about 70-90 days. Anker wireless mouse also comes with a 2.4 G dependable receiver that is responsible for its wireless connectivity feature. This mouse can move smoothly across a large number of surfaces, given that the surface is not too uneven.

Moreover, this ergonomic mouse comes with fantastic Dots per Inch (DPI) control technology. It offers its users a three-level DPI control option, which means that you can actively choose your preferred DPI level. This allows you to effectively choose the sensitivity level of the mouse cursor for customized user experience.

Anker mouse also comes with a battery-saving feature; if you leave it unattended for 8 minutes, the mouse will automatically shut down. Also, this mouse has additional controls to make web browsing more convenient. What really stands out about this mouse is its significantly low price.

PROs	CONs
Replaceable batteries DPI control technology Battery-saving feature Low price	Tracking needs work Design requires a little getting used to

No products found.

No products found.

This semi-vertical mouse by Newtral is ergonomically designed to reduce the stress on your hand caused by regular usage. The curve of the mouse greatly reduces the pronation of the user’s hand and effectively reduces muscle stress.

The mouse offers optimal comfort to its users. It comes with a patented shape that allows the user to grip it with a relaxed semi-bent shape instead of a rounded or straight angle, both of which cause unnecessary stress.

Moreover, this mouse comes with a magnetic, removable palm rest, which offers precise grip to the user. You will get the ultimate precision and control for gaming by simply anchoring the mouse with your wrist and little finger. The magnetic palm support offers the ultimate comfort for convenient office usage.

This wireless mouse has a total of 6 buttons. The user has the option to change the function of all the buttons by simply installing the NEWTRAL mouse driver. This allows you to customize the mouse to fit your exact needs.

It also has an adjustable DPI; you get to alternate between 800, 1600, and 2400 DPI. It comes with a 2.4G wireless receiver that you can simply plug into your device to start using the mouse.

This comes in three different sizes, so if you’re looking for an ergonomic mouse for large hands, you can choose their large version.

PROs	CONs
Shaped for comfort 3-year warranty Adjustable DPI Removable palm rest	Laser tracking might slow down over time Not fast enough for gaming

Logitech MX Master 2S Wireless Mouse

Logitech MX Master 2S mouse comes with multiple helpful features. It has a rather distinctive and elegant ergonomic design; it is large and has a uniquely-curved shape.

It has seamless tracking that allows tracking on the surface. Apart from the standard grayish black and white colors, it also comes in a striking midnight teal color.

This mouse has a spacious carved-in space on its left side for convenient thumb placement. This makes the mouse pretty easy to use for long hours. This wireless mouse comes with a large number of buttons, improving its functionality.

It also has the most recent cross-control system technology, which allows it to seamlessly work on up to three computers at a time! Moreover, this mouse comes with a useful Bluetooth connectivity option, which also makes it easy to connect it to multiple devices.

The Logitech MX Master 2S mouse also comes with a replaceable battery that has an enduring battery timing of 70 days.

What’s more is that this mouse offers its user a swift and seamless scroll with an efficient and quick drag. The hyper-active scrolling, precise tracking ability, and additional buttons of this mouse make it an incredible choice for gamers.

PROs	CONs
Perfect for gamers Simultaneous use on multiple devised Elegant design Quality precision tracking	Ideal for right-handers only The Logitech software lags

No products found.

No products found.

The Roccat Kone ergonomic gaming mouse comes with an exclusive optical sensor that offers a huge 12,000 DPI. This makes the pointer of this mouse extremely precise. It allows you to move your mouse with 100% accuracy and gives you an insurmountable advantage when it comes to gaming.

This mouse comes with a convenient tri-button thumb area, which has two large buttons suitable for the largest of hands and an ergonomically designed lower button that comes with a default easy-shift . It also features a button duplicate technology, enhancing user experience. It effectively doubles the number of configurable buttons from 12 to 24, which allows you to expand your weapon commands.

What truly sets this gaming mouse apart, though, is its AIMO intelligent lighting system. It allows the mouse to auto-react to the user’s touch and enhances your gaming experience. The mouse features 4 separately configured LED light spots and a glowing wheel, all of which you can program with the ROCCAT SWARM software.

It also has incredible 32-bit memory, which allows you to save and run weapon commands or macros while on the move. Additionally, it has a fitted tracking and control unit that effectively increases its accuracy.

PROs	CONs
32-bit memory Intelligent lighting system Convenient to use ergonomic buttons	Software glitches Too heavy for hardcore gaming

SteelSeries Rival 310 Gaming Mouse

This SteelSeries mouse offers highly effective and quick tracking due to the TrueMove3 Sensor, which allows you to track as accurately as possible. It also offers a range of 3,500 to 12,000 CPI and 350 IPS.

Moreover, this 5-inch mouse comes with superior and the latest jerk fall to enhance natural mouse maneuvering, without lagging the response time. It is ergonomically designed to offer a comfortable right-hand grip, without compromising on balance and speed.

The mouse features click switches with special split-trigger buttons that are designed to deliver the ultimate level of stability and a consistent and quick click feel. It also comes with a full range of 16.8 million lighting options.

The user can customize the lighting to enhance your gaming experience. You can save your performance and customized settings directly to the mouse for gaming events. What’s more is that this mouse is incredibly lightweight, which helps the user move it quite effortlessly.

PROs	CONs
Ideal for gaming Lightweight Fast and accurate tracking	Buttons start to falter with repeated usage Grip falls off For right-handers only

Logitech G602 Lag-Free Wireless Gaming Mouse

This wireless gaming mouse by Logitech has an amazing battery life; it offers up to 250 hours of uninterrupted power, that too in performance mode. Plus, it offers the user accurate and precise tracking, which allows you to gain an edge over your competitors.

The mouse is ergonomically designed to provide maximum comfort to the user over long hours of usage. The Logitech G602 mouse offers a natural palm-shaped grip and has conveniently-placed sculpted buttons. You can now enjoy your long gaming sessions without worrying about aching hands and arms.

The buttons of this mouse are pretty durable as they have been tested to withstand an intense number of 20 million clicks! The mouse offers its user 11 customizable control options. Simply download the Logitech gaming software to configure one-button triggers for any game command. You can also store your customized gaming profile on the mouse.

The advanced 2.4 GHz wireless receiver is designed to deliver a lag-free connection. For a no-lag gaming experience, plug in the receiver via the extender cable. The mouse also allows you to conserve power without compromising on quality. It uses the Delta Zero sensor to enhance the user’s experience; it offers highly accurate cursor control and battery optimization.

It also offers 5 different DPI settings – from 250 DPI for precise targeting to 2500 DPI for incredible, high-speed maneuvers. You can sue the two conveniently placed buttons to alter the DPI. It also offers the user two usage modes – Performance and Endurance. When gaming, use the performance mode for enhanced performance. For regular usage, switch to endurance mode, which will effectively prolong the battery life up to a remarkable 1440 hours.

PROs	CONs
Two different modes Precise and fast-tracking 5 DPI settings Numerous customizable controls	Not long-lasting Might start to lag overtime

CORSAIR Dark Core - RGB Wireless Gaming Mouse

The Corsair ergonomic gaming mouse comes with a 2.4GHz wireless Bluetooth that allows the user to have the ultimate gaming experience. It also comes with a wired USB connection. This mouse has a custom, gaming-level 16000 DPI optical sensors, with 1 DPI resolution steps, to enable high-accuracy gaming performance. You can easily customize it to virtually any sort of mouse pad.

The contoured shape of the mouse and the two interchangeable side grips provide the user with a customized fit – both left and right-handed individuals can use it with ease. The mouse is compatible with OS X, Windows, and all other Bluetooth 4.0 and higher enabled device.

It is also compatible with Xbox One; you can easily play mouse-enabled games on your Xbox. This mouse also offers the user plenty of onboard storage, which allows you to save your gaming profiles for universal access on the go. The mouse also offers up to 24 hours of battery power to its users.

PROs	CONs
Good for gaming Optimized tracing and performance Perfect for both left and right-handers	Software is cumbersome Faulty cursor Not long-lasting at all

If you are looking for the best mouse for large hands, you can refer to the above-mentioned list. Do take a look at the pros and cons to make the right decision!

Other ergonomic mouse reviews:

• Best Ergonomic Mouse for Small Hands
• Best Ergonomic Mouse For Wrist Pain
• Best Ergonomic Mouse for Left-Handed People
• Microsoft Sculpt Ergonomic Mouse Review
• Kensington Pro Fit Ergo Vertical Wireless Trackball Mouse Review